Systematic literature review protocol design

Design a systematic literature review following PRISMA guidelines. Protocol steps: 1. Define research question using PICO framework (Population, Intervention, Comparison, Outcome). 2. Develop search strategy: identify 3-5 databases (PubMed, Scopus, Web of Science), create Boolean search terms, set inclusion/exclusion criteria. 3. Screen titles/abstracts independently by 2 reviewers, resolve conflicts with third reviewer. 4. Full-text review using predefined criteria. 5. Data extraction using standardized forms (study design, sample size, outcomes, bias assessment). 6. Quality assessment using appropriate tools (Cochrane Risk of Bias, Newcastle-Ottawa Scale). 7. Synthesize findings narratively or through meta-analysis if appropriate. Document decisions transparently. Register protocol in PROSPERO before starting.